Endocrine Abstracts

Introduction: Adrenal vascular cysts are rare, in most cases incidentally discovered during abdominal imaging for other reasons. We present a case of adrenal endovascular cyst with initial suspicious features of adrenal malignancy and subsequent management and complications.Case report: This 72-year-old male was initially admitted with a weight loss over 2 months and new onset fever and rigors and right leg pain. He was noted to have an abdominal mass. H...

Background: In a vast majority of cases, hypopituitarism is caused by a tumour or a vascular event of the pituitary gland. We present a case of hypopituitarism caused by an uncommon cause identified on imaging studies.Case: A 58-year-old Caucasian woman presented with a 2-day history of diplopia, headache and vomiting with a background history of tiredness and lethargy over the past 4–6 months. Past medical history included type-II diabetes, hyperte...

5alpha-Reductase1 (5aR1) catalyses glucocorticoid metabolism, potentially modulating glucocorticoid clearance and therefore affecting the activity of the hypothalamic–pituitary–adrenal (HPA) axis. 5aR1 is up regulated in obesity associated with activation of the hypothalamic–pituitary–adrenal (HPA) axis. Here we investigated if inhibition of 5aR1 impairs glucocorticoid clearance and suppresses the HPA axis.Age-matched male and female ...